CP-673451, a Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor, Induces Apoptosis in <i>Opisthorchis viverrini</i>-Associated Cholangiocarcinoma via Nrf2 Suppression and Enhanced ROS

• मुख्य लेखकों: Jinchutha Duangdara (लेखक), Boonyakorn Boonsri (लेखक), Apinya Sayinta (लेखक), Kittiya Supradit (लेखक), Pakpoom Thintharua (लेखक), Supeecha Kumkate (लेखक), Chinnawut Suriyonplengsaeng (लेखक), Noppadol Larbcharoensub (लेखक), Somkit Mingphruedhi (लेखक), Narongsak Rungsakulkij (लेखक), Paramin Muangkaew (लेखक), Pongsatorn Tangtawee (लेखक), Watoo Vassanasiri (लेखक), Wikran Suragul (लेखक), Tavan Janvilisri (लेखक), Rutaiwan Tohtong (लेखक), David O. Bates (लेखक), Kanokpan Wongprasert (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) play essential roles in promoting cholangiocarcinoma (CCA) cell survival by mediating paracrine crosstalk between tumor and cancer-associated fibroblasts (CAFs), indicating the potential of PDGFR as a target for CCA treatment. Clini...