CP-673451, a Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor, Induces Apoptosis in <i>Opisthorchis viverrini</i>-Associated Cholangiocarcinoma via Nrf2 Suppression and Enhanced ROS

• Main Authors: Jinchutha Duangdara (Author), Boonyakorn Boonsri (Author), Apinya Sayinta (Author), Kittiya Supradit (Author), Pakpoom Thintharua (Author), Supeecha Kumkate (Author), Chinnawut Suriyonplengsaeng (Author), Noppadol Larbcharoensub (Author), Somkit Mingphruedhi (Author), Narongsak Rungsakulkij (Author), Paramin Muangkaew (Author), Pongsatorn Tangtawee (Author), Watoo Vassanasiri (Author), Wikran Suragul (Author), Tavan Janvilisri (Author), Rutaiwan Tohtong (Author), David O. Bates (Author), Kanokpan Wongprasert (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) play essential roles in promoting cholangiocarcinoma (CCA) cell survival by mediating paracrine crosstalk between tumor and cancer-associated fibroblasts (CAFs), indicating the potential of PDGFR as a target for CCA treatment. Clini...