Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood-Air Barrier Hyperpermeability

• Main Authors: Tiantian Wang (Author), Chunxia Liu (Author), Ling-hui Pan (Author), Zhen Liu (Author), Chang-long Li (Author), Jin-yuan Lin (Author), Yi He (Author), Jing-yuan Xiao (Author), Siyi Wu (Author), Yi Qin (Author), Zhao Li (Author), Fei Lin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Lung ischemia reperfusion injury (LIRI) is a complex pathophysiological process activated by lung transplantation and acute lung injury. The p38 mitogen-activated protein kinase (MAPK) is involved in breakdown of the endothelial barrier during LIRI, but the mechanism is still unclear. Th...