Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers

• Main Authors: Tianxing Liu (Author), Kensei Hashizume (Author), Eva Krieg (Author), Huijun Chen (Author), Yuki Mukaida (Author), Kirstin Thelen (Author), Frauke Friedrichs (Author), Stefan Willmann (Author), Stephan Schwers (Author), Alexander Solms (Author), Rosie Yu (Author)
• Format: Book
• Published: Wiley, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The inhibition of coagulation factor XI (FXI) presents an attractive approach for anticoagulation as it is not expected to increase the risk of clinically relevant bleeding and is anticipated to be at least as effective as currently available anticoagulants. Fesomersen is a conjugated antis...