Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers

• मुख्य लेखकों: Tianxing Liu (लेखक), Kensei Hashizume (लेखक), Eva Krieg (लेखक), Huijun Chen (लेखक), Yuki Mukaida (लेखक), Kirstin Thelen (लेखक), Frauke Friedrichs (लेखक), Stefan Willmann (लेखक), Stephan Schwers (लेखक), Alexander Solms (लेखक), Rosie Yu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2024-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract The inhibition of coagulation factor XI (FXI) presents an attractive approach for anticoagulation as it is not expected to increase the risk of clinically relevant bleeding and is anticipated to be at least as effective as currently available anticoagulants. Fesomersen is a conjugated antis...