Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach

• Main Authors: Delia Preti (Author), Romeo Romagnoli (Author), Riccardo Rondanin (Author), Barbara Cacciari (Author), Ernest Hamel (Author), Jan Balzarini (Author), Sandra Liekens (Author), Dominique Schols (Author), Francisco Estévez-Sarmiento (Author), José Quintana (Author), Francisco Estévez (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of microtubule function using tubulin targeting agents has received growing attention in the last several decades. The indole scaffold has been recognized as an important scaffold in the design of novel compounds acting as antimitotic agents. Indole-based chalcones, in which one of the ar...