Extract from leaf of Psidium guajava L depresses the guinea pig atrial contractility by interfering with potassium and calcium channels

• Main Authors: Antonio Nei Santana Gondim (Author), Vanda Rodrigues de Oliveira (Author), Sellyanna Domeny dos Santos (Author), Bagnólia Araújo da Silva (Author), Carla Maria Lins de Vasconcelos (Author), Eduardo Antonio Conde-Garcia (Author)
• Format: Book
• Published: Universidade de São Paulo, 2009-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The negative inotropic effect of aqueous fraction (AqF) obtained from the acetic extract of Psidium guajava L leaf was investigated on the guinea pig left atrium. Myocardial force was measured isometrically (27 ± 0.1 ºC, 2 Hz). AqF (100 μg/ml) reduced contractility of about 85 ± 9.4 % (n = 4, p <...