QSAR modelling, molecular docking, molecular dynamic and ADMET prediction of pyrrolopyrimidine derivatives as novel Bruton's tyrosine kinase (BTK) inhibitors

• मुख्य लेखकों: Mourad Aloui (लेखक), Mohammed Er-rajy (लेखक), Hamada Imtara (लेखक), Amina Goudzal (लेखक), Sara Zarougui (लेखक), Mohamed El fadili (लेखक), David E. Arthur (लेखक), Ramzi A. Mothana (लेखक), Omar M. Noman (लेखक), Mahmoud Tarayrah (लेखक), Elhalaoui Menana (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2024-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

In recent years, there has been a focus on developing and discovering novel Bruton's tyrosine kinase (BTK) inhibitors, as they offer an effective treatment strategy for B-cell malignancies. BTK plays a crucial role in B cell receptor (BCR)-mediated activation and proliferation by regulating dow...