QSAR modelling, molecular docking, molecular dynamic and ADMET prediction of pyrrolopyrimidine derivatives as novel Bruton's tyrosine kinase (BTK) inhibitors

• Main Authors: Mourad Aloui (Author), Mohammed Er-rajy (Author), Hamada Imtara (Author), Amina Goudzal (Author), Sara Zarougui (Author), Mohamed El fadili (Author), David E. Arthur (Author), Ramzi A. Mothana (Author), Omar M. Noman (Author), Mahmoud Tarayrah (Author), Elhalaoui Menana (Author)
• 格式: 圖書
• 出版: Elsevier, 2024-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

In recent years, there has been a focus on developing and discovering novel Bruton's tyrosine kinase (BTK) inhibitors, as they offer an effective treatment strategy for B-cell malignancies. BTK plays a crucial role in B cell receptor (BCR)-mediated activation and proliferation by regulating dow...