Genotypic analysis of Asp299Gly and Thr399Ile polymorphisms of TLR4 in Egyptian patients with rheumatoid arthritis and systemic lupus

• Main Authors: Hanan A. Taha (Author), Rania E. Sheir (Author), Sanaa S Abdel Shafy (Author), Lamya M. Mohamed (Author)
• פורמט: ספר
• יצא לאור: SpringerOpen, 2014-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Background Toll-like receptors (TLRs) are essential molecules of the innate immune system that stimulate numerous inflammatory pathways and harmonize systemic defense against a wide array of pathogens. TLRs may also recognize a number of self-proteins and endogenous nucleic acids. Inappropriate stim...