Development of a UPLC-MS/MS method for the determination of orelabrutinib in rat plasma and its application in pharmacokinetics

• Principais autores: Ya-nan Liu (Autor), Yingying Hu (Autor), Jing Wang (Autor), Chaojie Chen (Autor), Jianping Cai (Autor), Ren-ai Xu (Autor), Zhongqiu Lu (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The aim of the present study was to establish an ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the determination of orelabrutinib in rat plasma using futibatinib as internal standard (IS), and to apply it for a pharmacokinetic study in rats. Orelabrutinib w...