Dexmedetomidine Mitigated NLRP3-Mediated Neuroinflammation via the Ubiquitin-Autophagy Pathway to Improve Perioperative Neurocognitive Disorder in Mice

• Main Authors: Lieliang Zhang (Author), Fan Xiao (Author), Jing Zhang (Author), Xifeng Wang (Author), Jun Ying (Author), Gen Wei (Author), Shoulin Chen (Author), Xiangfei Huang (Author), Wen Yu (Author), Xing Liu (Author), Qingcui Zheng (Author), Guohai Xu (Author), Shuchun Yu (Author), Fuzhou Hua (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Surgery and anesthesia-induced perioperative neurocognitive disorder (PND) are closely related to NOD-like receptors (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome microglia inflammatory response. Inhibiting the occurrence of neuroinflammation is an important treatment meth...