The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

• Main Authors: Xiaoling Cao (Author), Vi Nguyen (Author), Joseph Tsai (Author), Chao Gao (Author), Yan Tian (Author), Yuping Zhang (Author), Wayne Carver (Author), Hippokratis Kiaris (Author), Taixing Cui (Author), Wenbin Tan (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: As the pandemic evolves, post-acute sequelae of CoV-2 (PASC) including cardiovascular manifestations have emerged as a new health threat. This study aims to study whether the Spike protein plus obesity can exacerbate PASC-related cardiomyopathy. Methods: A Spike protein-pseudotyped (Spp)...