Identification and Biological Characterization of the Pyrazolo[3,4-<i>d</i>]pyrimidine Derivative SI388 Active as Src Inhibitor

• Main Authors: Claudia Contadini (Author), Claudia Cirotti (Author), Anna Carbone (Author), Mehrdad Norouzi (Author), Annarita Cianciusi (Author), Emmanuele Crespan (Author), Cecilia Perini (Author), Giovanni Maga (Author), Daniela Barilà (Author), Francesca Musumeci (Author), Silvia Schenone (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Src is a non-receptor tyrosine kinase (TK) whose involvement in cancer, including glioblastoma (GBM), has been extensively demonstrated. In this context, we started from our <i>in-house</i> library of pyrazolo[3,4-<i>d</i>]pyrimidines that are active as Src and/or Bcr-Abl TK...