Design, synthesis, and evaluation of cyclic C7-bridged monocarbonyl curcumin analogs containing an o-methoxy phenyl group as potential agents against gastric cancer

• Main Authors: Xin Gan (Author), Yuna Wu (Author), Min Zhu (Author), Bo Liu (Author), Miaomiao Kong (Author), Zixuan Xi (Author), Ke Li (Author), Haibao Wang (Author), Tiande Su (Author), Jiali Yao (Author), Fatehi Khushafah (Author), Baozhu Yi (Author), Jiabing Wang (Author), Wulan Li (Author), Jianzhang Wu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractThe structure-activity relationship (SAR) between toxicity and the types of linking ketones of C7 bridged monocarbonyl curcumin analogs (MCAs) was not clear yet. In the pursuit of effective and less cytotoxic chemotherapeutics, we conducted a SAR analysis using various diketene skeletons of...