Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex

• Main Authors: Amber Kerkhofs (Author), Ana C. Xavier (Author), Beatriz S. da Silva (Author), Paula M. Canas (Author), Sander Idema (Author), Johannes C. Baayen (Author), Samira G. Ferreira (Author), Rodrigo A. Cunha (Author), Huibert D. Mansvelder (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Caffeine is the most widely used psychoactive drug, bolstering attention and normalizing mood and cognition, all functions involving cerebral cortical circuits. Whereas studies in rodents showed that caffeine acts through the antagonism of inhibitory A1 adenosine receptors (A1R), neither the role of...