Computational strategies for PROTAC drug discovery
Proteolysis-targeting chimeras (PROTACs), a novel targeted protein degradation technology for potential clinical drug discovery, is composed of a protein-targeting ligand covalently linked to an E3 ligase ligand. Through recruiting E3 ligase to target proteins, PROTACs elicit ubiquitination and subs...
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Compuscript Ltd,
2023-02-01T00:00:00Z.
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