Computational strategies for PROTAC drug discovery

Proteolysis-targeting chimeras (PROTACs), a novel targeted protein degradation technology for potential clinical drug discovery, is composed of a protein-targeting ligand covalently linked to an E3 ligase ligand. Through recruiting E3 ligase to target proteins, PROTACs elicit ubiquitination and subs...

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Main Authors: Jia Wu (Author), Wanhe Wang (Author), Chung-Hang Leung (Author)
Format: Book
Published: Compuscript Ltd, 2023-02-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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