AhR/miR-23a-3p/PKCα axis contributes to memory deficits in ovariectomized and normal aging female mice

• Main Authors: Shuai Zhang (Author), Xiaobin An (Author), Siyu Huang (Author), Lu Zeng (Author), Yi Xu (Author), Dan Su (Author), Yang Qu (Author), Xin Tang (Author), Jing Ma (Author), Junkai Yang (Author), Jing Ai (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mechanism of estrogen deficiency-induced cognitive impairment is still not fully elucidated. In this study, we assessed the effect of microRNA (miRNA) on the memory of long-term estrogen-deficient mice after ovariectomy (OVX) and normal aging. We observed that 5-month OVX and 22-month-old normal...