SUMO E3 Ligase PIASy Mediates High Glucose-Induced Activation of NF-κB Inflammatory Signaling in Rat Mesangial Cells

• Main Authors: Wei Huang (Author), Yaling Liang (Author), Jianhua Dong (Author), Luping Zhou (Author), Chenlin Gao (Author), Chunxia Jiang (Author), Meijuan Chen (Author), Yang Long (Author), Yong Xu (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Sumoylation is extensively involved in the regulation of NF-κB signaling. PIASy, as a SUMO E3 ligase, has been proved to mediate sumoylation of IκB kinase γ (IKKγ) and contribute to the activation of NF-κB under genotoxic agent stimulation. However, the association of PIASy and NF-κB sig...