Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death

• Ngā kaituhi matua: Hyun Joo Shin (Author), Eun Ae Jeong (Author), Jong Youl Lee (Author), Hyeong Seok An (Author), Hye Min Jang (Author), Yu Jeong Ahn (Author), Jaewoong Lee (Author), Kyung Eun Kim (Author), Gu Seob Roh (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2021-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The hippocampal cell death that follows kainic acid (KA)-induced seizures is associated with blood-brain barrier (BBB) leakage and oxidative stress. Lipocalin-2 (LCN2) is an iron-trafficking protein which contributes to both oxidative stress and inflammation. However, LCN2's role in KA-induced...