Human Motor Neuron Progenitor Transplantation Leads to Endogenous Neuronal Sparing in 3 Models of Motor Neuron Loss

• Main Authors: Tanya J. Wyatt (Author), Sharyn L. Rossi (Author), Monica M. Siegenthaler (Author), Jennifer Frame (Author), Rockelle Robles (Author), Gabriel Nistor (Author), Hans S. Keirstead (Author)
• Format: Book
• Published: Hindawi Limited, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Motor neuron loss is characteristic of many neurodegenerative disorders and results in rapid loss of muscle control, paralysis, and eventual death in severe cases. In order to investigate the neurotrophic effects of a motor neuron lineage graft, we transplanted human embryonic stem cell-derived moto...