Macrophage metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in mice

• Main Authors: Boichot Elisabeth (Author), Guenon Isabelle (Author), Nenan Soazig (Author), Manoury Boris (Author), Planquois Jean-Michel (Author), Bertrand Claude P (Author), Lagente Vincent (Author)
• Format: Book
• Published: BMC, 2006-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Pulmonary fibrosis is characterized by excessive deposition of extracellular matrix in the interstitium resulting in respiratory failure. The role of remodeling mediators such as metalloproteinases (MMPs) and their inhibitors (TIMPs)...