Enhanced Delivery of 4-Thioureidoiminomethylpyridinium Perchlorate in Tuberculosis Models with IgG Functionalized Poly(Lactic Acid)-Based Particles

• Main Authors: Leonid Churilov (Author), Viktor Korzhikov-Vlakh (Author), Ekaterina Sinitsyna (Author), Dmitry Polyakov (Author), Oleg Darashkevich (Author), Mikhail Poida (Author), Galina Platonova (Author), Tatiana Vinogradova (Author), Vladimir Utekhin (Author), Natalia Zabolotnykh (Author), Vsevolod Zinserling (Author), Peter Yablonsky (Author), Arto Urtti (Author), Tatiana Tennikova (Author)
• Format: Book
• Published: MDPI AG, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The compound 4-thioureidoiminomethylpyridinium perchlorate (perchlozone©) is a novel anti-tuberculosis drug that is active in multiple drug resistance cases, but the compound is hepatotoxic. To decrease the systemic load and to achieve targeting, we encapsulated the drug into poly(lactic ac...