CaMKIIδ-dependent dysregulation of atrial Na+ homeostasis promotes pro-arrhythmic activity in an obstructive sleep apnea mouse model

• Main Authors: Philipp Hegner (Author), Florian Ofner (Author), Benedikt Schaner (Author), Mathias Gugg (Author), Maximilian Trum (Author), Anna-Maria Lauerer (Author), Lars Siegfried Maier (Author), Michael Arzt (Author), Simon Lebek (Author), Stefan Wagner (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundObstructive sleep apnea (OSA) has been linked to various pathologies, including arrhythmias such as atrial fibrillation. Specific treatment options for OSA are mainly limited to symptomatic approaches. We previously showed that increased production of reactive oxygen species (ROS) stimulat...