GL67 lipid-based liposomal formulation for efficient siRNA delivery into human lung cancer cells

• Main Authors: Somayah J. Jarallah (Author), Ahmad M. Aldossary (Author), Essam A. Tawfik (Author), Reem M. Altamimi (Author), Wijdan K. Alsharif (Author), Nouf M. Alzahrani (Author), Homood M. As Sobeai (Author), Wajhul Qamar (Author), Ahmed J. Alfahad (Author), Manal A. Alshabibi (Author), Sarah H. Alqahtani (Author), Abdullah A. Alshehri (Author), Fahad A. Almughem (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The efficient delivery of small interfering RNA (siRNA) to the targeted cells significantly affects the regulation of the overexpressed proteins involved in the progression of several genetic diseases. SiRNA molecules in naked form suffer from low internalization across the cell membrane, high susce...