Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion

• Main Authors: Lilianne Frégeau-Proulx (Author), Aurélie Lacouture (Author), Line Berthiaume (Author), Cindy Weidmann (Author), Mario Harvey (Author), Kevin Gonthier (Author), Jean-François Pelletier (Author), Bertrand Neveu (Author), Cynthia Jobin (Author), Dominic Bastien (Author), Alain Bergeron (Author), Yves Fradet (Author), Louis Lacombe (Author), Isabelle Laverdière (Author), Chantal Atallah (Author), Frédéric Pouliot (Author), Étienne Audet-Walsh (Author)
• Format: Book
• Published: Elsevier, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The prostate is metabolically unique: it produces high levels of citrate for secretion via a truncated tricarboxylic acid (TCA) cycle to maintain male fertility. In prostate cancer (PCa), this phenotype is reprogrammed, making it an interesting therapeutic target. However, how the truncat...