Successful Brain Delivery of Andrographolide Loaded in Human Albumin Nanoparticles to TgCRND8 Mice, an Alzheimer's Disease Mouse Model

• Main Authors: Anna Rita Bilia (Author), Pamela Nardiello (Author), Vieri Piazzini (Author), Manuela Leri (Author), Maria Camilla Bergonzi (Author), Monica Bucciantini (Author), Fiorella Casamenti (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Andrographolide (AG) was encapsulated in human albumin nanoparticles (AG NPs), and their crossing properties of the blood-brain barrier (BBB), brain distribution, and effects in TgCRND8 mice were evaluated. The development of appropriate NP formulations is mandatory because of the scarce BBB permeab...