Successful Brain Delivery of Andrographolide Loaded in Human Albumin Nanoparticles to TgCRND8 Mice, an Alzheimer's Disease Mouse Model

• Автори: Anna Rita Bilia (Автор), Pamela Nardiello (Автор), Vieri Piazzini (Автор), Manuela Leri (Автор), Maria Camilla Bergonzi (Автор), Monica Bucciantini (Автор), Fiorella Casamenti (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Andrographolide (AG) was encapsulated in human albumin nanoparticles (AG NPs), and their crossing properties of the blood-brain barrier (BBB), brain distribution, and effects in TgCRND8 mice were evaluated. The development of appropriate NP formulations is mandatory because of the scarce BBB permeab...