The Screening of Broadly Neutralizing Antibodies Targeting the SARS-CoV-2 Spike Protein by mRNA Immunization in Mice

• Main Authors: Zhiyin An (Author), Yu Zhang (Author), Xiang Yu (Author), Jia Xia (Author), Yanan Yin (Author), Guoming Li (Author), Jing Lu (Author), Xuemei Fan (Author), Yingjie Xu (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neutralizing antibodies (nAbs), the popular antiviral drugs used for the treatment of COVID-19, are effective in reducing viral load and hospitalization. Currently, most nAbs are screened from convalescent or vaccinated individuals through single B-cell sequencing which requires cutting-edge facilit...