(CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis

(CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis

The myotonic dystrophies are prototypic toxic RNA gain-of-function diseases. Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are caused by different unstable, noncoding microsatellite repeat expansions - (CTG)DM1 in DMPK and (CCTG)DM2 in CNBP. Although transcription of mutant repeats into (CUG)DM1...

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Main Authors: Vildan Betul Yenigun (Author), Mario Sirito (Author), Alla Amcheslavky (Author), Tomek Czernuszewicz (Author), Jordi Colonques-Bellmunt (Author), Irma García-Alcover (Author), Marzena Wojciechowska (Author), Clare Bolduc (Author), Zhihong Chen (Author), Arturo López Castel (Author), Ralf Krahe (Author), Andreas Bergmann (Author)
Format: Book
Published: The Company of Biologists, 2017-08-01T00:00:00Z.
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