Muscle Proteome Analysis of Facioscapulohumeral Dystrophy Patients Reveals a Metabolic Rewiring Promoting Oxidative/Reductive Stress Contributing to the Loss of Muscle Function

• Main Authors: Manuela Moriggi (Author), Lucia Ruggiero (Author), Enrica Torretta (Author), Dario Zoppi (Author), Beatrice Arosio (Author), Evelyn Ferri (Author), Alessandra Castegna (Author), Chiara Fiorillo (Author), Cecilia Gelfi (Author), Daniele Capitanio (Author)
• Format: Book
• Published: MDPI AG, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Facioscapulohumeral muscular dystrophy (FSHD) is caused by the epigenetic de-repression of the double homeobox 4 (DUX4) gene, leading to asymmetric muscle weakness and atrophy that begins in the facial and scapular muscles and progresses to the lower limbs. This incurable condition can severely impa...