Safety, pharmacokinetics, and pharmacodynamics of sofnobrutinib, a novel non‐covalent BTK inhibitor, in healthy subjects: First‐in‐human phase I study

Safety, pharmacokinetics, and pharmacodynamics of sofnobrutinib, a novel non‐covalent BTK inhibitor, in healthy subjects: First‐in‐human phase I study

Abstract Bruton's tyrosine kinase (BTK) is a potential therapeutic target for allergic and autoimmune diseases. This first‐in‐human phase I study evaluated safety, pharmacokinetic, and pharmacodynamic profiles of sofnobrutinib (formerly AS‐0871), a highly selective, orally available, non‐covale...

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Main Authors: Kyoko Miyamoto (Author), Robert M. Miller (Author), Christine Voors‐Pette (Author), Jart A. F. Oosterhaven (Author), Marieke van denDobbelsteen (Author), Katsuhiro Mihara (Author), Marian Geldof (Author), Yuji Sato (Author), Naomi Matsuda (Author), Shirou Kirita (Author), Masaaki Sawa (Author), Akinori Arimura (Author)
Format: Book
Published: Wiley, 2024-11-01T00:00:00Z.
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