Antipruritic Effect of Topical Acetaminophen Gel in Histaminergic and Non-histaminergic Itch Provocation: A Double-blind, Vehicle-controlled Pilot Study

• Main Authors: Leigh A. Nattkemper (Author), Kaining Zhi (Author), Kaeli E. Romero (Author), Serena M. Shah (Author), Teresa Ju (Author), Kayla Fourzali (Author), Rachel Shireen Golpanian (Author), Flor MacQuhae (Author), Yiong Huak Chan (Author), David B. Lebo (Author), Gil Yosipovitch (Author)
• Format: Book
• Published: Medical Journals Sweden, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is a need for new topical antipruritics that are effective on many types of itch. This study examined the antipruritic efficacy of a new formulation of topical acetaminophen. In vitro skin permeability studies showed that 2.5% and 5% formulations are able to rapidly deliver an adequate amount...