Clic4, a novel protein that sensitizes β-cells to apoptosis

• Main Authors: Dhaval Patel (Author), Damien Ythier (Author), Flora Brozzi (Author), Decio L. Eizirik (Author), Bernard Thorens (Author)
• Format: Book
• Published: Elsevier, 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Chloride intracellular channel protein 4 (Clic4) is a ubiquitously expressed protein involved in multiple cellular processes including cell-cycle control, cell differentiation, and apoptosis. Here, we investigated the role of Clic4 in pancreatic β-cell apoptosis. Methods: We used βTC-tet...