DNA nuclear targeting sequences for enhanced non-viral gene transfer: An in vitro and in vivo study

• Main Authors: Yann T. Le Guen (Author), Chantal Pichon (Author), Philippe Guégan (Author), Kévin Pluchon (Author), Tanguy Haute (Author), Sandrine Quemener (Author), Juliette Ropars (Author), Patrick Midoux (Author), Tony Le Gall (Author), Tristan Montier (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An important bottleneck for non-viral gene transfer commonly relates to translocation of nucleic acids into the nuclear compartment of target cells. So-called 3NFs are optimized short nucleotide sequences able to interact with the transcription factor nuclear factor κB (NF-κB), which can enhance the...