Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma

• Main Authors: Ke Lu (Author), Ming Zhang (Author), Hongyu Qin (Author), Siyu Shen (Author), Haiqing Song (Author), Hua Jiang (Author), Chunxiang Zhang (Author), Guozhi Xiao (Author), Liping Tong (Author), Qing Jiang (Author), Di Chen (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclin D1 has been recognized as an oncogene due to its abnormal upregulation in different types of cancers. Here, we demonstrated that cyclin D1 is SUMOylated, and we identified Itch as a specific E3 ligase recognizing SUMOylated cyclin D1 and mediating SUMO-induced ubiquitination and proteasome de...