Cerebrospinal Fluid and Brain Tissue Penetration of Tenofovir, Lamivudine, and Efavirenz in Postmortem Tissues with Cryptococcal Meningitis

• Главные авторы: Melanie R. Nicol (Автор), Katelyn A. Pastick (Автор), Joneé Taylor (Автор), Olivie C. Namuju (Автор), Joshua Rhein (Автор), Darlisha A. Williams (Автор), David B. Meya (Автор), David R. Boulware (Автор), Robert Lukande (Автор)
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• Опубликовано: Wiley, 2019-09-01T00:00:00Z.
• Предметы: article
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The central nervous system (CNS) is a known HIV reservoir, yet little is known about drug exposure in the brain. Our primary objective was to quantify exposure of three common antiretrovirals in brain tissue and compare exposures to plasma and cerebrospinal fluid (CSF). We also sought to identify po...