Cerebrospinal Fluid and Brain Tissue Penetration of Tenofovir, Lamivudine, and Efavirenz in Postmortem Tissues with Cryptococcal Meningitis

• Main Authors: Melanie R. Nicol (Author), Katelyn A. Pastick (Author), Joneé Taylor (Author), Olivie C. Namuju (Author), Joshua Rhein (Author), Darlisha A. Williams (Author), David B. Meya (Author), David R. Boulware (Author), Robert Lukande (Author)
• Format: Book
• Published: Wiley, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The central nervous system (CNS) is a known HIV reservoir, yet little is known about drug exposure in the brain. Our primary objective was to quantify exposure of three common antiretrovirals in brain tissue and compare exposures to plasma and cerebrospinal fluid (CSF). We also sought to identify po...