ROS/JNK/C-Jun Pathway is Involved in Chaetocin Induced Colorectal Cancer Cells Apoptosis and Macrophage Phagocytosis Enhancement

• Main Authors: Huihui Wang (Author), Chuangyu Wen (Author), Siyu Chen (Author), Weiqian Li (Author), Qiyuan Qin (Author), Lu He (Author), Fang Wang (Author), Junxiong Chen (Author), Weibiao Ye (Author), Wende Li (Author), Junsheng Peng (Author), Xiangling Yang (Author), Huanliang Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is an urgent need for novel agents for colorectal cancer (CRC) due to the increasing number of cases and drug-resistance related to current treatments. In this study, we aim to uncover the potential of chaetocin, a natural product, as a chemotherapeutic for CRC treatment. We showed that, regar...