EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors

• Autores principales: Emily Capone (Autor), Rossano Lattanzio (Autor), Fabio Gasparri (Autor), Paolo Orsini (Autor), Cosmo Rossi (Autor), Valentina Iacobelli (Autor), Vincenzo De Laurenzi (Autor), Pier Giorgio Natali (Autor), Barbara Valsasina (Autor), Stefano Iacobelli (Autor), Gianluca Sala (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2021-04-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

HER-3 is becoming an attractive target for antibody-drug conjugate (ADC)-based therapy. Indeed, this receptor and its ligands are found to be overexpressed in several malignancies, and re-activation of its downstream signaling axis is known to play a critical role in modulating the sensitivity of ta...