Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents

• Main Authors: Jiabing Wang (Author), Lili Huang (Author), Chanchan Cheng (Author), Ge Li (Author), Jingwen Xie (Author), Mengya Shen (Author), Qian Chen (Author), Wulan Li (Author), Wenfei He (Author), Peihong Qiu (Author), Jianzhang Wu (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Scavenging reactive oxygen species (ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury (CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI t...