MFG-E8 and HMGB1 Are Involved in the Mechanism Underlying Alcohol-Induced Impairment of Macrophage Efferocytosis

• প্রধান লেখক: Xiao Wang (লেখক), Heng-Fu Bu (লেখক), Wei Zhong (লেখক), Akihiro Asai (লেখক), Zhanxiang Zhou (লেখক), Xiao-Di Tan (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: BMC, 2013-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Efferocytosis is a unique phagocytic process for macrophages to remove apoptotic cells in inflammatory loci. This event is maintained by milk fat globule-EGF factor 8 (MFG-E8), but attenuated by high mobility group box 1 (HMGB1). Alcohol abuse causes injury and inflammation in multiple tiss...