MFG-E8 and HMGB1 Are Involved in the Mechanism Underlying Alcohol-Induced Impairment of Macrophage Efferocytosis

• Main Authors: Xiao Wang (Author), Heng-Fu Bu (Author), Wei Zhong (Author), Akihiro Asai (Author), Zhanxiang Zhou (Author), Xiao-Di Tan (Author)
• Format: Book
• Published: BMC, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Efferocytosis is a unique phagocytic process for macrophages to remove apoptotic cells in inflammatory loci. This event is maintained by milk fat globule-EGF factor 8 (MFG-E8), but attenuated by high mobility group box 1 (HMGB1). Alcohol abuse causes injury and inflammation in multiple tiss...