Differential Effects of Angelicin Analogues on NF-κB Activity and IL-8 Gene Expression in Cystic Fibrosis IB3-1 Cells

• Main Authors: Ilaria Lampronti (Author), Maria Giulia Manzione (Author), Gianni Sacchetti (Author), Davide Ferrari (Author), Susanna Spisani (Author), Valentino Bezzerri (Author), Alessia Finotti (Author), Monica Borgatti (Author), Maria Cristina Dechecchi (Author), Giorgia Miolo (Author), Giovanni Marzaro (Author), Giulio Cabrini (Author), Roberto Gambari (Author), Adriana Chilin (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The angelicin analogue 4,6,4'-trimethylangelicin (TMA) was recently reported as a strong inhibitor of nuclear factor-κB (NF-κB) activity and of the expression of the interleukin-8 (IL-8) gene in bronchial epithelial cells in which the inflammatory response has been challenged with P. aeruginosa...