Suicide genes: monitoring cells in patients with a safety switch

• Main Authors: Linda Groppe Eissenberg (Author), Michael eRettig (Author), Farrokh eDehdashti (Author), David ePiwnica-Worms (Author), John F. DiPersio (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clinical trials increasingly incorporate suicide genes either as direct lytic agents for tumors or as safety switches in therapies based on genetically modified cells. Suicide genes can also be used as non-invasive reporters to monitor the biological consequences of administering genetically modifie...