RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia

• Main Authors: Önay Veli (Author), Öykü Kaya (Author), Ana Beatriz Varanda (Author), Ximena Hildebrandt (Author), Peng Xiao (Author), Yann Estornes (Author), Matea Poggenberg (Author), Yuan Wang (Author), Manolis Pasparakis (Author), Mathieu J.M. Bertrand (Author), Henning Walczak (Author), Alessandro Annibaldi (Author), Alessandra K. Cardozo (Author), Nieves Peltzer (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Receptor-interacting protein kinase 1 (RIPK1) orchestrates the decision between cell survival and cell death in response to tumor necrosis factor (TNF) and other cytokines. Whereas the scaffolding function of RIPK1 is crucial to prevent TNF-induced apoptosis and necroptosis, its kinase ac...