Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region

• Main Authors: Tao Zhang (Author), Zhongxia Zhou (Author), Fabao Zhao (Author), Zihao Sang (Author), Erik De Clercq (Author), Christophe Pannecouque (Author), Dongwei Kang (Author), Peng Zhan (Author), Xinyong Liu (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HIV-1 reverse transcriptase (RT) plays a crucial role in the viral replication cycle, and RT inhibitors can represent a promising pathway in treating AIDS. To explore the primer grip region of HIV-1 RT, using -CH₂O- as a linker, substituted benzene or pyridine rings were intro...