Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities

• Glavni autori: Romeo Romagnoli (Autor), Paola Oliva (Autor), Filippo Prencipe (Autor), Stefano Manfredini (Autor), Federica Budassi (Autor), Andrea Brancale (Autor), Salvatore Ferla (Autor), Ernest Hamel (Autor), Diana Corallo (Autor), Sanja Aveic (Autor), Lorenzo Manfreda (Autor), Elena Mariotto (Autor), Roberta Bortolozzi (Autor), Giampietro Viola (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2022-08-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

A further investigation aiming to generate new potential antitumor agents led us to synthesize a new series of twenty-two compounds characterized by the presence of the 7-(3',4',5'-trimethoxyphenyl)-[1,2,4]triazolo[1,5-<i>a</i>]pyrimidine pharmacophore modified at its 2-po...