Synthesis and biological evaluations of oleanolic acid indole derivatives as hyaluronidase inhibitors with enhanced skin permeability

• Main Authors: Hao He (Author), Huifang Li (Author), Toyosi Akanji (Author), Shengli Niu (Author), Zhujun Luo (Author), Dongli Li (Author), Navindra P. Seeram (Author), Panpan Wu (Author), Hang Ma (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oleanolic acid (OA) is a natural cosmeceutical compound with various skin beneficial activities including inhibitory effect on hyaluronidase but the anti-hyaluronidase activity and mechanisms of action of its synthetic analogues remain unclear. Herein, a series of OA derivatives were synthesised and...