Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish

• Asıl Yazarlar: Jason R. Becker (Yazar), Rahul C. Deo (Yazar), Andreas A. Werdich (Yazar), Daniela Panàkovà (Yazar), Shannon Coy (Yazar), Calum A. MacRae (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: The Company of Biologists, 2011-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

SUMMARY To assess the effects during cardiac development of mutations that cause human cardiomyopathy, we modeled a sarcomeric gene mutation in the embryonic zebrafish. We designed morpholino antisense oligonucleotides targeting the exon 13 splice donor site in the zebrafish cardiac troponin T (tnnt...