Effect of enzalutamide on PK of P‐gp and BCRP substrates in cancer patients: CYP450 induction may not always predict overall effect on transporters

Effect of enzalutamide on PK of P‐gp and BCRP substrates in cancer patients: CYP450 induction may not always predict overall effect on transporters

Abstract Drug‐drug interaction (DDI) is an important consideration for clinical decision making in prostate cancer treatment. The objective of this study was to evaluate the effect of enzalutamide, an oral androgen receptor inhibitor, on the pharmacokinetics (PK) of digoxin (P‐glycoprotein [P‐gp] pr...

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Main Authors: Srinivasu Poondru (Author), Vitalii Ghicavii (Author), Reza Khosravan (Author), Pooja Manchandani (Author), Nakyo Heo (Author), Selina Moy (Author), Tomasz Wojtkowski (Author), Melanie Patton (Author), Gabriel P. Haas (Author)
Format: Book
Published: Wiley, 2022-05-01T00:00:00Z.
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