Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making

• Autors principals: Anna Kondic (Autor), Dean Bottino (Autor), John Harrold (Autor), Jeffrey D. Kearns (Autor), CJ Musante (Autor), Aleksandrs Odinecs (Autor), Saroja Ramanujan (Autor), Jangir Selimkhanov (Autor), Birgit Schoeberl (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

The goal of this mini-review is to summarize the collective experience of the authors for how modeling and simulation approaches have been used to inform various decision points from discovery to First-In-Human clinical trials. The article is divided into a high-level overview of the types of proble...