Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making

• Main Authors: Anna Kondic (Author), Dean Bottino (Author), John Harrold (Author), Jeffrey D. Kearns (Author), CJ Musante (Author), Aleksandrs Odinecs (Author), Saroja Ramanujan (Author), Jangir Selimkhanov (Author), Birgit Schoeberl (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The goal of this mini-review is to summarize the collective experience of the authors for how modeling and simulation approaches have been used to inform various decision points from discovery to First-In-Human clinical trials. The article is divided into a high-level overview of the types of proble...