Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease

• Main Authors: Xiaokang Li (Author), Jian Lu (Author), Yixiang Xu (Author), Jiaying Wang (Author), Xiaoxia Qiu (Author), Lei Fan (Author), Baoli Li (Author), Wenwen Liu (Author), Fei Mao (Author), Jin Zhu (Author), Xu Shen (Author), Jian Li (Author)
• Format: Book
• Published: Elsevier, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug repurposing is an efficient strategy for new drug discovery. Our latest study found that nitazoxanide (NTZ), an approved anti-parasite drug, was an autophagy activator and could alleviate the symptom of Alzheimer's disease (AD). In order to further improve the efficacy and discover new che...