Inhibition of p66Shc Oxidative Signaling via CA-Induced Upregulation of miR-203a-3p Alleviates Liver Fibrosis Progression

• Main Authors: Zhecheng Wang (Author), Yan Zhao (Author), Huanyu Zhao (Author), Junjun Zhou (Author), Dongcheng Feng (Author), Fan Tang (Author), Yang Li (Author), Li Lv (Author), Zhao Chen (Author), Xiaodong Ma (Author), Xiaofeng Tian (Author), Jihong Yao (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously found that inhibition of p66Shc confers protection against hepatic stellate cell (HSC) activation during liver fibrosis. However, the effect of p66Shc on HSC proliferation, as well as the mechanism by which p66Shc is modulated, remains unknown. Here, we elucidated the effect of p66Shc...