Comprehensive Investigation of Stereoselective Food Drug Interaction Potential of Resveratrol on Nine P450 and Six UGT Isoforms in Human Liver Microsomes

• Main Authors: Seung-Bae Ji (Author), So-Young Park (Author), Subin Bae (Author), Hyung-Ju Seo (Author), Sin-Eun Kim (Author), Gyung-Min Lee (Author), Zhexue Wu (Author), Kwang-Hyeon Liu (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The stereoselectivity of the food drug inhibition potential of resveratrol on cytochrome P450s and uridine 5'-diphosphoglucuronosyl transferases was investigated in human liver microsomes. Resveratrol enantiomers showed stereoselective inhibition of CYP2C9, CYP3A, and UGT1A1. The inhibitions of...